Acute effect of prednisone and deflazacort on glucose tolerance in prediabetic subjects

@article{Pagano2004AcuteEO,
  title={Acute effect of prednisone and deflazacort on glucose tolerance in prediabetic subjects},
  author={Gianfranco Pagano and A. Lombardi and G. M. Ferraris and Bruno Pietro Imbimbo and Paolo Cavallo Perin},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={22},
  pages={469-471}
}
SummaryThe diabetogenic effect of deflazacort (DF), an oxazolinic synthetic corticosteroid, was studied in 12 healthy adult subjects with a positive family history of diabetes mellitus. Three oral glucose tests (oGTT) were performed at 9.00 a. m., after a 12 h fast, following randomized administration of Placebo (PL), or Deflazacort (DF 36+36 mg) or Prednisone (PN 30+30 mg) 12 and 2 h before the test. Plasma glucose (BG), insulin (IRI), non-esterified fatty acids (NEFA), total cholesterol (CL… Expand
Comparison of acute and subacute effects of deflazacort and prednisone on glucose metabolism in man
TLDR
It is concluded that on acute and 7-day administration to healthy subjects DF, in an anti-inflammatory dose equivalent to PN, shows significantly less influence on glucose metabolism. Expand
Deflazacort vs Prednisone: Effect on Blood Glucose Control in Insulin-Treated Diabetics
TLDR
The results indicate that deflazacort, when employed in an anti-inflammatory dose equivalent to prednisone, should prove advantageous in insulin-treated diabetics who require steroid treatment. Expand
An open comparision of the diabetogenic effect of deflazacort and prednisone at a dosage ratio of 1.5 mg:1 mg
TLDR
D and PN have similar effects on glucose tolerance when an equipotency ratio of 1.5 mg D:1”mg PN is employed, suggesting previous studies employing a ratio of1.2:1 “mg” may have understimated the adverse effects of D on glucose metabolism. Expand
Serum glucose, insulin and C-peptide response to oral glucose after intravenous administration of hydrocortisone and methylprednisolone in man
TLDR
The dose-related decreases in glucose tolerance are more marked after a single i.v. injection of MP than HC at the same anti-inflammatory dose, MP 20 or 40 mg as well as HC 100 or 200 mg do not impair glucose tolerance, but the former is associated with higher serum insulin levels, suggesting insulin resistance. Expand
Effects of prednisolone and deflazacort on osteocalcin metabolism in sheep
TLDR
It is concluded that plasma OC levels and OC PPR in sheep were more sensitive to the effects of deflazacort than to prednisolone, indicating that predisonsolone had similarly potent effects on both bone and glucose metabolism while deflAZacort exhibited differential potency on the two systems. Expand
Change in glucose metabolism after long-term treatment with deflazacort and betamethasone
TLDR
The results suggest that the degree of glucose intolerance and insulin resistance depends on the steroid used and on the dose given, although long-term treatment with deflazacort has a smaller effect on glucose metabolism than betamethasone. Expand
Comparison of Serum Pharmacodynamic Biomarkers in Prednisone-Versus Deflazacort-Treated Duchenne Muscular Dystrophy Boys
TLDR
This study identified GC-responsive biomarkers, some associated with safety, that highlight differential PD response between Dfz and Pred and identified seventeen candidate proteins that were differentially altered between the two drugs. Expand
Effects of a new heterocyclic glucocorticoid, deflazacort (DFC), on the functions of lymphocytes from patients with rheumatoid arthritis (RA).
TLDR
The data reported in this paper show that the oral administration of DFC to patients with RA affects the in vitro behavior of their lymphocytes, which differs in both intensity and kinetic characteristics from the immunomodulating effect observed with PDN (control). Expand
The effect of food on the relative bioavailability of deflazacort
TLDR
It is indicated that co-administration of deflazacort tablets with high-fat and low-fat meals leads to a small decrease in rate but does not affect its extent of absorption, and terminal half-life was not affected. Expand
Effects of deflazacort vs. methylprednisone: a randomized study in kidney transplant patients
TLDR
The data suggest that deflazacort therapy might improve linear growth and lean body mass and prevent excessive bone loss and fat accumulation and lead to an improvement in lipoprotein profile without reduction in insulin sensitivity. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 24 REFERENCES
Comparison of subacute effects of oxazacort and prednisone on mineral metabolism in man
TLDR
It is concluded that the increase in urinary calcium excretion, and presumably the negative calcium balance, produced by a 2-week administration of oxazacort is significantly less pronounced than that produced by an equivalent dose of prednisone. Expand
Effects of a new glucocorticoid, oxazacort, on some variables connected with bone metabolism in man: a comparison with prednisone.
TLDR
It is demonstrated that oxazacort in short-term teatment with a high dose has no significant effect on the urinary elimination of calcium and hydroxypyroline in experimental conditions in which prednisone produces statistically significant and clinically relevant increase. Expand
Effect of dexamethasone and cortisone on insulin receptors in normal human male.
Results of a recent study suggested that depending upon the glucocorticoid or the model used, opposite changes occur in insulin binding; in fact, the increase in insulin receptor number on monocytesExpand
Decreased Insulin Binding of Human Erythrocytes After Dexamethasone or Prednisone Ingestion
TLDR
It is suggested that acute alteration of insulin receptor function could occur in erythrocytes by small amounts of dexamethasone or prednisone through a mechanism consistent with a decreases in receptor affinity rather than a decrease in the number of receptors. Expand
Insulin resistance in the aged: the role of the peripheral insulin receptors.
TLDR
The result indicates that insulin resistance in the aged may be attributed at least in part to a reduction in the number of insulin receptors on the target cells, as proposed by other workers in the case of old fat rats. Expand
Prednisone increases the number of insulin receptors on monocytes from normal subjects.
TLDR
Intention of prednisone in doses which are usually employed in clinical treatment (40 mg/day) was associated with a significant increase int the number of insulin receptors. Expand
The Lilly Lecture 1976: Insulin, Glucagon, and Somatostatin in Normal Physiology and Diabetes Mellitus
TLDR
It is concluded that insulin deficiency is the primary pathophysiologic disturbance in diabetes and while glocagon may worsen the consequences of insulin lack, it is neither sufficient nor necessary for the development of diabetes. Expand
Insulin binding to target cells (general survey, problems and results in spontaneous obesity).
TLDR
A new approach to the problem of 'insulin resistance' in obesity has been proposed, and this has shown that a reduction in the number of receptors on the target cells may contribute to peripheral insulin insensitivity. Expand
Studies of an vitro effect of glucocorticoids on gluconeogenesis.
  • R. Haynes
  • Chemistry, Medicine
  • Endocrinology
  • 1962
TLDR
It was found that glucocorticoids added in low concentrations to the incubation system stimulated carbohydrate formation when either L-alanine or L-serine was supplied as substrate, and carbohydrate that was formed was shown to be glucose or compounds yielding glucose upon acid hydrolysis. Expand
The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes.
TLDR
A decrease in insulin binding is associated with corticosteroid excess, and it is possible that this decreased binding is related to the insulin resistance which results from cortcosteroid administration; the return of insulin binding toward normal after chronic D treatment could well be related toThe improvement in insulin resistance seen during chronic corticosterone administration to humans. Expand
...
1
2
3
...