Acute effect of intracerebroventricular administration of lead on the drinking behavior of rats induced by dehydration or central cholinergic and angiotensinergic stimulation.

@article{Fregoneze1994AcuteEO,
  title={Acute effect of intracerebroventricular administration of lead on the drinking behavior of rats induced by dehydration or central cholinergic and angiotensinergic stimulation.},
  author={Josmara Bartolomei Fregoneze and M. Da. Cunha and Christian F Bulcao and Hilda Silva Ferreira and Emilio de Castro e Silva},
  journal={Physiology & behavior},
  year={1994},
  volume={56 1},
  pages={129-33}
}
In the present paper, the acute effect of third ventricle injections of lead acetate (5, 10, 100, 1000 ng/rat) on the drinking behavior of adult, male, Wistar rats was investigated. Lead generates a prompt and significant reduction in water intake induced by three different circumstances: dehydration (14 h of water deprivation) and after carbachol (2 micrograms/rat, ICV) or angiotensin II (10 ng/rat, ICV) administration. These results show that lead may produce very fast actions in the central… CONTINUE READING