Acute effect of high glucose on long-term cell growth: a role for transient glucose increase in proximal tubule cell injury.

@article{Samikkannu2006AcuteEO,
  title={Acute effect of high glucose on long-term cell growth: a role for transient glucose increase in proximal tubule cell injury.},
  author={Thangavel Samikkannu and Justin Thomas and Gopalkrishna Bhat and Vaughan Wittman and Thomas J. Thekkumkara},
  journal={American journal of physiology. Renal physiology},
  year={2006},
  volume={291 1},
  pages={
          F162-75
        }
}
Although chronic exposure of renal cells to high glucose has been shown to cause cell injury, the effect of acute exposure has not been elucidated. In this study, we demonstrate that acute (10 min) exposure of human proximal tubule epithelial cells (hPTEC) to high glucose (25 mM) induces a time-dependent dual effect consisting of an early proliferation and a late apoptosis. Acute exposure of hPTEC to high glucose induced a twofold increase in DNA synthesis and cell number at 12 h. However… CONTINUE READING

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