Acute effect of glimepiride on insulin-stimulated glucose metabolism in glucose-tolerant insulin-resistant offspring of patients with type 2 diabetes.

@article{Overkamp2002AcuteEO,
  title={Acute effect of glimepiride on insulin-stimulated glucose metabolism in glucose-tolerant insulin-resistant offspring of patients with type 2 diabetes.},
  author={D. Overkamp and A. Volk and E. Maerker and P. Heide and H. Wahl and K. Rett and H. H{\"a}ring},
  journal={Diabetes care},
  year={2002},
  volume={25 11},
  pages={
          2065-73
        }
}
OBJECTIVE This study addressed whether acute infusion of glimepiride influences glucose metabolism independent of its effect on insulin secretion. RESEARCH DESIGN AND METHODS Ten healthy, glucose-tolerant but insulin-resistant probands were subjected to a placebo-controlled, double-blind, cross-over study. Each individual received infusions of either 0.15 mol/l saline or glimepiride in randomized order on two separate occasions. A three-step hyperinsulinemic (0.5, 1.0, and 1.5 mU. kg(-1). min… Expand
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