Acute effect of 1,25-dihydroxyvitamin D3, prednisone, and 1,25-dihydroxyvitamin D3 plus prednisone on serum osteocalcin in normal individuals.

@article{Nielsen1991AcuteEO,
  title={Acute effect of 1,25-dihydroxyvitamin D3, prednisone, and 1,25-dihydroxyvitamin D3 plus prednisone on serum osteocalcin in normal individuals.},
  author={Henning Kaspersen Nielsen and Kim Brixen and Moustapha Kassem and Leif Mosekilde},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1991},
  volume={6 5},
  pages={435-41}
}
Suppression of osteoblastic function plays an important pathogenic role for the development of glucocorticosteroid-induced osteoporosis. Serum osteocalcin (OC) is a sensitive marker of bone formation. The diurnal rhythm in serum OC can be changed by administration of single doses of either 1,25-(OH)2D3 or prednisone. However, the two steroids have opposing effects: 1,25-(OH)2D3 increases and prednisone decreases serum OC. The aim of the present study was to examine whether 1,25-(OH)2D3 can… CONTINUE READING

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