Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants

@article{Leung2009AcuteDA,
  title={Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants},
  author={Sumie Leung and Rodney J. Croft and Val{\'e}rie Guille and Kirsty Elizabeth Scholes and Barry V. O’Neill and K. Luan Phan and Pradeep J. Nathan},
  journal={Psychopharmacology},
  year={2009},
  volume={208},
  pages={233-244}
}
Schizophrenia is commonly associated with impairments in pre-attentive change detection, as represented by reduced mismatch negativity (MMN). While the neurochemical basis of MMN has been linked to N-methyl-d-aspartic acid (NMDA) receptor function, the roles of the dopaminergic and/or the serotonergic systems are not fully explored in humans. The aim of the present study was to investigate the effects of acutely depleting dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) alone or… CONTINUE READING

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