Acute dopamine D(1) and D(2) receptor stimulation does not modulate mismatch negativity (MMN) in healthy human subjects.

@article{Leung2007AcuteDD,
  title={Acute dopamine D(1) and D(2) receptor stimulation does not modulate mismatch negativity (MMN) in healthy human subjects.},
  author={Sumie Leung and Rodney J. Croft and Torsten Baldeweg and Pradeep J. Nathan},
  journal={Psychopharmacology},
  year={2007},
  volume={194 4},
  pages={443-51}
}
RATIONALE Schizophrenia is commonly associated with an impairment in pre-attentive change detection, as represented by reduced mismatch negativity (MMN), an auditory event related potential. While the neurochemical basis of MMN has been linked to the integrity of the glutamatergic system involving N-methyl-D-aspartate (NMDA) receptors, the role of the dopaminergic system and in particular, the role of D(1) and D(2) receptors on MMN is yet to be determined. OBJECTIVES The aim of the present… CONTINUE READING

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