Acute decreases in cerebrospinal fluid glutathione levels after intracerebroventricular morphine for cancer pain.

@article{Goudas1999AcuteDI,
  title={Acute decreases in cerebrospinal fluid glutathione levels after intracerebroventricular morphine for cancer pain.},
  author={Leonidas C Goudas and Aym{\'e} Langlade and Alain Serri{\'e} and Wayne Matson and Paul Milbury and Cl. Thurel and Pierre Sandouk and Daniel B. Carr},
  journal={Anesthesia and analgesia},
  year={1999},
  volume={89 5},
  pages={1209-15}
}
UNLABELLED Intracerebroventricular (ICV) morphine administration is effective for the management of refractory cancer pain. Recent preclinical observations of acute depletion of the major endogenous intracellular antioxidant glutathione (GSH) in brain and peripheral organs after ICV morphine in rodents led us to apply microchemical methods to profile the neurochemical effects of ICV morphine in three patients treated for intractable cancer pain. Assessment of morphine, morphine-6-glucuronide… CONTINUE READING

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