Acute conduction block in vitro following exposure to antiganglioside sera.

@article{Arasaki1993AcuteCB,
  title={Acute conduction block in vitro following exposure to antiganglioside sera.},
  author={Keisuke Arasaki and Susumu Kusunoki and Norio Kudo and Ichiro Kanazawa},
  journal={Muscle & nerve},
  year={1993},
  volume={16 6},
  pages={587-93}
}
We studied the role of antiganglioside antibodies in the pathogenesis of autoimmune neuropathies using an in vitro preparation of a rat sciatic nerve. Human and rabbit sera with high titers of the antibodies were applied to a restricted segment of the sciatic nerve mounted in a recording chamber, and the compound nerve action potentials of the myelinated and unmyelinated fibers were observed. Myelinated fiber conduction became blocked at the segment within a few hours, whereas the unmyelinated… CONTINUE READING

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