Acute complications of Epstein-Barr virus infectious mononucleosis

  title={Acute complications of Epstein-Barr virus infectious mononucleosis},
  author={H. B. Jenson},
  journal={Current Opinion in Pediatrics},
  • H. Jenson
  • Published 1 June 2000
  • Medicine
  • Current Opinion in Pediatrics
Infectious mononucleosis caused by Epstein-Barr virus (EBV) usually resolves over a period of weeks or months without sequelae but may occasionally be complicated by a wide variety of neurologic, hematologic, hepatic, respiratory, and psychological complications. The strength of association of EBV with many of these complications remains based on scattered case reports, often using unsophisticated diagnostic tests, and the evidence for causation in many instances is unconvincing. There is… 

Mononucleosis and Epstein-Barr virus infection: treatment and medication

The role of antiviral treatment and corticosteroids is debatable and not recommended in general, while the development of vaccination is under investigation.

Epstein-Barr Virus Mononucleosis: Neurologic Complications

2 cases of acute EBV infection with predominant and serious neurologic complications in pediatric patients are presented, both of which have the classic hallmarks of acute IM.

Airway Obstruction in a Young Adult With Infectious Mononucleosis by Epstein-Barr Virus

Infectious mononucleosis (IM) denotes a clinical syndrome characterized by systemic somatic complaints with prominent fever, fatigue and malaise, lymphadenopathy, and sore throat, which may result from primary infection with Epstein-Barr virus, Toxoplasma gondii, human immunodeficiency virus, adenovirus, viral hepatitis, and possibly rubella virus.

Severe thrombocytopenia as a complication of acute Epstein-Barr virus infection

Repeated administration of methylprednisolone was followed by full recovery of the platelet count and normalization of formerly elevated transaminases, and this differential diagnosis should be considered in every patient presenting with acute thrombocytopenia.

Acute hepatitis: a rare complication of Epstein-Barr virus (EBV) infection.

A patient with acute hepatitis following EBV-IM in a previously healthy woman who presented with fever, generalized weakness, nausea, sore throat, yellowing of skin, and a generalized skin rash is described.

Genitourinary manifestations of Epstein-Barr virus infections

The available literature and data regarding EBV in the female genital tract is reviewed and its pathogenic role in the cervix, uterus, fallopian tubes, and ovaries is poorly understood.

Acute Respiratory Failure and Cerebral Hemorrhage due to Primary Epstein-Barr Virus Infection

A young female adolescent is reported in whom an acute EBV infection led to severe bilateral pneumonitis, a systemic inflammatory response and intracerebral bleeding, and results of quantitative viral DNA determinations in plasma are presented.

A Case Report of Pediatric Epstein Barr Virus (EBV) Related Cholestasis from Al-Adan Hospital, Kuwait

A 7-year-old girl treated by Gastroenterology, Hepatology, and Nutrition Unit of Al-Adan Hospital pediatric Department presented with prolonged fever, lymphadenopathy, generalized edema, hyperbilurubi- nemia and elevated liver enzymes secondary to EBV infection represents a rare presentation of common viral infection in pediatric population.

Epstein-Barr Virus Infectious Mononucleosis in a Splenectomized Patient

It is described here an atypical IM case; an asplenic but healthy male presented with acute primary EBV infection and was afebrile, there was an absence of lymphadenopathy, and there was relatively marked lymphocytosis in his peripheral blood.

Recent advances in the understanding of infectious mononucleosis: are prospects improved for treatment or control?

  • P. Auwaerter
  • Medicine
    Expert review of anti-infective therapy
  • 2006
This review will highlight recent advances in the understanding of primary Epstein–Barr virus infection, and whether prospective treatments or vaccine strategies may affect native infection and its sequelae.



Severe thrombocytopenia in Epstein-Barr virus-induced mononucleosis.

Clinical and laboratory data from seven patients seen between 1976 and 1985 whose lowest platelet counts varied from 3 to 25 x 10(9) per liter were evaluated, finding that two of six patients tested had antiplatelet antibodies during the acute phase of their illnesses.

Acute Epstein-Barr virus infection complicated by severe thrombocytopenia.

Although acute EBV infections are generally benign and self-limiting, thrombocytopenia, a potentially serious complication, should not be overlooked.

Primary Epstein-Barr-virus infections in acute neurologic diseases.

It is evident that the virus must be considered in the diagnosis of various acute neurologic diseases affecting children and young adults, even in the absence of heterophil-antibody response or other signs of infectious mononucleosis.

Severe neurological complications in association with Epstein-Barr virus infection.

Two patients with unusual and severe neurological complications in association with serological evidence of EBV-infection are described: a 32-year old female developed a bilateral optic neuritis combined with a transverse myelitis and a 72-year-old man developed mononeuritis multiplex, autonomic neuropathy and a salt-wasting nephropathy.

Epstein-Barr Virus Infection Associated with Rhabdomyolysis and Acute Renal Failure

Another case of rhabdomyolysis and nonoliguric renal failure in a child with Epstein-Barr virus infection is reported.

Epstein‐Barr virus‐associated hemophagocytic syndrome and fatal infectious mononucleosis

The relationship between EBV‐associated VAHS and fatal IM is discussed, and Epstein‐Barr virus is now thought to be one of the major causes for the development of this unique syndrome.

Severe neutropenia in infectious mononucleosis.

The data suggest that EBV infection is the proximate cause of the severe neutropenia in some patients with infectious mononucleosis and that in such cases close observation and early treatment of suspected superinfections is necessary.

Infectious mononucleosis and fatal myocarditis.

A 14-year-old girl initially had exudative pharyngitis and splenomegaly and developed refractory ventricular fibrillation and extensive histiocytic and lypmhocytic infiltration of the myocardium demonstrated.

Epstein‐Barr Virus Infection in Chediak‐Higashi Syndrome Mimicking Acute Lymphocytic Leukemia

  • N. Kinugawa
  • Medicine
    The American journal of pediatric hematology/oncology
  • 1990
A case of Chediak-Higashi syndrome in the accelerated phase that was associated with Epstein-Barr virus (EBV) infection, which revealed an atypical lymphoid infiltration favoring EBV infection as the primary diagnosis underscores the fatal consequences ofEBV infection in CHS.

Nervous system involvement in infectious mononucleosis. The heralding and-or major manifestation.

Infectious mononucleosis should be one of the etiological considerations in children and young adults presenting with short histories and showing neurological deficits reflecting involvement of almost any part of the nervous system.