Acute colitis produced by chemotactic peptides in rats and mice.

@article{Chester1985AcuteCP,
  title={Acute colitis produced by chemotactic peptides in rats and mice.},
  author={John F. Chester and Jeffrey S. Ross and Ronald A. Malt and SigmundA. Weitzman},
  journal={The American journal of pathology},
  year={1985},
  volume={121 2},
  pages={
          284-90
        }
}
Colonic inflammation was produced in rats and mice by peptides chemotactic for polymorphonuclear leukocytes. Instillation of formylmethionyl-leucyl-phenylalanine (FMLP) and formylnorleucyl-leucyl-phenylalanine (FNLP) into isolated segments of rat colon caused marked mucosal edema and polymorphonuclear leukocyte infiltration within 2 hours. Higher concentrations of FNLP caused ulceration and necrosis as well. Formylmethionine (FMet), a compound with less chemotactic activity, caused much less… CONTINUE READING

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