Acute cold/restraint stress inhibits host resistance to Listeria monocytogenes via β1-adrenergic receptors

@article{Cao2003AcuteCS,
  title={Acute cold/restraint stress inhibits host resistance to Listeria monocytogenes via β1-adrenergic receptors},
  author={Ling yong Cao and Chad A Hudson and David A. Lawrence},
  journal={Brain, Behavior, and Immunity},
  year={2003},
  volume={17},
  pages={121-133}
}
We previously reported that acute cold/restraint stress (ACRS) significantly inhibits host resistance to Listeria monocytogenes (LM) in BALB/c mice and that the sympathetic nervous system plays a major role in this inhibition. Here, we have further investigated the involvement of adrenergic receptor (ADR) subtypes. beta-ADR antagonist propranolol, but not alpha-ADR antagonist phentolamine significantly enhanced host resistance of ACRS mice. Pro-inflammatory cytokine (IL-6, IL-1beta, and… CONTINUE READING

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