Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen

@article{Porrino2012AcuteCI,
  title={Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen},
  author={Linda J. Porrino and Robert E. Hampson and Ioan Opris and Sam A. Deadwyler},
  journal={Psychopharmacology},
  year={2012},
  volume={225},
  pages={105-114}
}
Acute and/or chronic exposure to cocaine can affect cognitive performance, which may influence rate of recovery during treatment. Effects of the GABA-B receptor agonist baclofen were assessed for potency to reverse the negative influence of acute, pre-session, intravenous (IV) injection of cocaine on cognitive performance in Macaca mulatta nonhuman primates. Animals were trained to perform a modified delayed match to sample (DMS) task incorporating two types of trials with varying degrees of… CONTINUE READING
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View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Neural correlates

RE Hampson, I Opris, SA Deadwyler
2010
View 10 Excerpts
Highly Influenced

GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice.

European journal of pharmacology • 2009
View 6 Excerpts
Highly Influenced

Development, optimization and use of preclinical behavioral models to maximize the productivity of drug discovery for Alzheimer’s disease

MD Lindner, RA McArthur, S Deadwyler, R Hampson, PN Tariot
Borsini F (eds) Animal and Translational Models of Behavioural Disorders (Vol • 2008
View 9 Excerpts
Highly Influenced

Comparison of neuronal correlates of cocaine and appetitive rewards in nonhuman primates

I Opris, RE Hampson, SA Deadwyler
Neurosci • 2009
View 4 Excerpts
Highly Influenced

Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers.

Journal of neuroimaging : official journal of the American Society of Neuroimaging • 2004
View 4 Excerpts
Highly Influenced

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