Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen

  title={Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen},
  author={Linda J. Porrino and Robert E. Hampson and Ioan Opris and Sam A. Deadwyler},
Acute and/or chronic exposure to cocaine can affect cognitive performance, which may influence rate of recovery during treatment. Effects of the GABA-B receptor agonist baclofen were assessed for potency to reverse the negative influence of acute, pre-session, intravenous (IV) injection of cocaine on cognitive performance in Macaca mulatta nonhuman primates. Animals were trained to perform a modified delayed match to sample (DMS) task incorporating two types of trials with varying degrees of… CONTINUE READING
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