Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats.

@article{Sabeti2002AcuteCD,
  title={Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats.},
  author={Jilla Sabeti and Greg A. Gerhardt and Nancy R. Zahniser},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={302 3},
  pages={1201-11}
}
Behavioral responses of rodents to cocaine are characterized by marked individual variability. Here, outbred male Sprague-Dawley rats were profiled based on concomitant recording of behavioral and electrochemical responses. Rats were categorized as either low or high cocaine responders (LCRs or HCRs, respectively) based on their differential locomotor responsiveness to an acute, low-dose injection of cocaine (10 mg/kg i.p.). LCRs and HCRs also differed in other cocaine-induced behaviors. The… CONTINUE READING
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