Acute cholestatic liver disease protects against glycerol-induced acute renal failure in the rat.

@article{Leung2001AcuteCL,
  title={Acute cholestatic liver disease protects against glycerol-induced acute renal failure in the rat.},
  author={Nelson Leung and Anthony J. Croatt and Jill J Haggard and Joseph P Grande and Karl A Nath},
  journal={Kidney international},
  year={2001},
  volume={60 3},
  pages={1047-57}
}
BACKGROUND It is widely held that liver disease predisposes toward acute tubular necrosis. The present study examines the effect of acute cholestatic liver disease on the susceptibility to glycerol-induced acute tubular necrosis in the rat. METHODS Acute cholestatic liver disease was induced by ligation of the common bile duct, while the intramuscular injection of hypertonic glycerol was used to induce acute tubular necrosis. Renal injury was assessed by plasma creatinine concentration and… CONTINUE READING

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