Acute cholestasis induced by lithocholic acid in the rat. A freeze-fracture replica and thin section study.

@article{Miyal1975AcuteCI,
  title={Acute cholestasis induced by lithocholic acid in the rat. A freeze-fracture replica and thin section study.},
  author={K Miyal and Winfried Mayr and Anne Louise Richardson},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1975},
  volume={32 4},
  pages={527-35}
}
Sodium lithocholate (LCA) was continuously infused intravenously (0.1 or 0.2 mumole per minute per 100 gm. body weight) in Wistar rats with a bile fistula for up to 4 hours. The higher dose induced complete cholestasis within 2 to 3 hours, whereas the low dose reduced the biliary output to less than 10 per cent of the preinfusion level by the 3rd hour. Ultrastructural changes which were primarily localized to the bile canaliculi and the pericanalicular region were seen 30 minutes after the… CONTINUE READING

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