Acute chest syndrome: sickle cell disease

@article{Paul2011AcuteCS,
  title={Acute chest syndrome: sickle cell disease},
  author={Rabindra N Paul and Oswaldo L. Castro and Anita Aggarwal and Patricia Ann Oneal},
  journal={European Journal of Haematology},
  year={2011},
  volume={87}
}
Acute chest syndrome (ACS) is a common complication and reason for hospital admission in patients with sickle cell disease (SCD). It is also the most common cause of death in this patient population. Most of the time, the trigger for ACS in an individual patient cannot be identified. However, although infection is the most common identifiable cause for ACS, other important triggers are vaso‐occlusive crisis (VOC) and asthma. This comprehensive review will focus on the pathogenesis, clinical… Expand
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Severe Acute Chest Syndrome in a Sickle Cell Patient That Required Repeated Exchange Transfusion
TLDR
This case report presents an interesting severe form of ACS that, quite unusually, required repeated exchanged blood transfusion to achieve clinical improvement. Expand
Acute Chest Syndrome in Sickle Cell Disease Patients Post Caesarean Delivery
TLDR
It is suggested that prompt recognition of ACS in a pregnant woman with SCD and collaborative medical and obstetric management are essential to optimize maternal and fetal outcomes. Expand
Pulmonary complications in adult patients with sickle cell disease
TLDR
The present review comprises the following pulmonary complications of SCD: i) acute chest syndrome, ii) venous thromboembolus, iii) asthma, iv) respiratory dysfunction, v) respiratory disorders during sleeping, vi) pulmonary hypertension. Expand
Sickle Cell Disease and Acute Chest Syndrome: Mechanisms and Pathogenenesis
TLDR
Experimental data indicate heme-induced ACS may involve vaso-occlusion and the release of neutrophil extracellular traps in the lung, and the heme hypothesis posits that the lung injury in ACS is caused by acute inflammation directly involvingextracellular heme, a prototypical erythroid DAMP molecule released by hemolysis. Expand
Rapid Fire: Sickle Cell Disease.
TLDR
The pathophysiology of emergent complaints are usually related to either an acute anemia or a vasoocclusive crisis and must be differentiated by the source. Expand
Pulmonary Complications and Lung Function Abnormalities in Children with Sickle Cell Disease
TLDR
Whether more aggressive treatment of anaemia would improve lung function and long-term outcomes merits testing, as well as the importance of identifying effective strategies to prevent and optimally treat ACS. Expand
Sickle Cell Disease in Children
TLDR
Clinical manifestations and therapeutic strategies for paediatric sickle cell disease as well as the evolving topic of gene-focused prevention and therapy are focused on. Expand
Pulmonary Complications of Haematologic Disorders
TLDR
Almost 40% of survivors of childhood leukaemia have some degree of abnormality on pulmonary function testing, but only 10–25% of children are symptomatic reporting cough or mild dyspnea; this is as a consequence of chemotherapy and irradiation. Expand
Red blood cell exchange to avoid intubating a COVID‐19 positive patient with sickle cell disease?
TLDR
A patient with sickle cell disease (HbSC) who developed COVID‐19 pneumonia and acute chest syndrome who was treated with emergent red blood cell exchange in order to avoid endotracheal intubation is reported. Expand
Prognostic value of hyponatremia during ACUTE PAINFUL EPISODES in sickle cell disease.
TLDR
Hyponatremia at admission in the medical department for an acute painful episode is a strong and independent prognostic factor of unfavorable outcome, and notably acute chest syndrome. Expand
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