Acute changes of blood ammonia may predict short-term adverse effects of valproic acid.

@article{Zaccara1984AcuteCO,
  title={Acute changes of blood ammonia may predict short-term adverse effects of valproic acid.},
  author={G. Zaccara and R. Campostrini and Marco Paganini and Fausto Moroni and T. Valenza and G Targioni and Graziano Arnetoli and Roberto Zappoli and Agostino Baruzzi},
  journal={Neurology},
  year={1984},
  volume={34 11},
  pages={1519-21}
}
Valproic acid (VPA) was given to 24 epileptic patients who were already being treated with other antiepileptic drugs. A standardized loading dose of VPA was administered, and venous blood was sampled at 0, 1, 2, 3, and 4 hours. Ammonia (NH3) was higher in patients who, during continuous therapy, complained of drowsiness (7 patients) than in those who were symptom-free (17 patients), although VPA plasma levels were similar in both groups. By measuring VPA-induced changes of blood NH3 content, it… CONTINUE READING