Acute changes of biventricular gene expression in volume and right ventricular pressure overload.

@article{RonconAlbuquerque2006AcuteCO,
  title={Acute changes of biventricular gene expression in volume and right ventricular pressure overload.},
  author={Roberto Roncon-Albuquerque and Mariana de Vasconcelos and Andr{\'e} P Lourenço and Ana Brand{\~a}o-Nogueira and Ant{\'o}nia Teles and Tiago Henriques-Coelho and Adelino F Leite-Moreira},
  journal={Life sciences},
  year={2006},
  volume={78 22},
  pages={
          2633-42
        }
}
OBJECTIVE We investigated the effects of acute volume and RV pressure overload on biventricular function and gene expression of BNP, pro-inflammatory cytokines (IL-6 and TNF-alpha), iNOS, growth factors (IGF-1, ppET-1), ACE and Ca2+-handling proteins (SERCA2a, phospholamban and calsequestrin). METHODS Male Wistar rats (n=45) instrumented with pressure tip micromanometers in right (RV) and left ventricular (LV) cavities were assigned to one of three protocols: i) Acute RV pressure overload… CONTINUE READING

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