Acute changes in Cerebrospinal Fluid 5-HIAA following Oral Paroxetine Challenge in Healthy Humans

@article{Carpenter2003AcuteCI,
  title={Acute changes in Cerebrospinal Fluid 5-HIAA following Oral Paroxetine Challenge in Healthy Humans},
  author={Linda L Carpenter and George M See Anderson and Jason M. Siniscalchi and Phillip B Chappell and Lawrence H. Price},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={339-347}
}
A number of studies have reported decreased human lumbar cerebrospinal fluid (CSF) concentrations of the major serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), following chronic administration of selective serotonin reuptake inhibitors (SSRIs). This decrease has been thought to be a consequence of elevated extracellular serotonin and to be mediated through terminal autoreceptor feedback inhibition of serotonin turnover. We wished to study the previously unexamined acute effects of… CONTINUE READING

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