Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase

@article{HafeziMoghadam2002AcuteCP,
  title={Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase},
  author={Ali Hafezi-Moghadam and Tommaso Simoncini and Zhihong Yang and Florian P Limbourg and J. -C. L. Plumier and Michela C. Rebsamen and Chung-Ming Hsieh and D S Chui and Kennard L. Thomas and Alyson Prorock and Victor E Laubach and Michael Ann Moskowitz and Brent A. French and Klaus Ley and James K. Liao},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={473-479}
}
Corticosteroids have been shown to exert beneficial effects in the treatment of acute myocardial infarction, but the precise mechanisms underlying their protective effects are unknown. Here we show that high-dose corticosteroids exert cardiovascular protection through a novel mechanism involving the rapid, non-transcriptional activation of endothelial nitric oxide synthase (eNOS). Binding of corticosteroids to the glucocorticoid receptor (GR) stimulated phosphatidylinositol 3-kinase and protein… CONTINUE READING
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