Acute cardiovascular effects of insulin-like growth factor I in patients with chronic heart failure.

@article{Donath1998AcuteCE,
  title={Acute cardiovascular effects of insulin-like growth factor I in patients with chronic heart failure.},
  author={Marc Y. Donath and Gabor S{\"u}tsch and Xinxiu Yan and Bruno Gomes Piva and H P Brunner and Y. Glatz and Juergen Zapf and Ferenc Follath and E. R. Froesch and Wolfgang Kiowski},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1998},
  volume={83 9},
  pages={
          3177-83
        }
}
Insulin-like growth factor I (IGF-I) enhances myofibrillar development in cardiomyocytes of rats in culture and in vivo. In addition, IGF-I has vasodilatory effects and improves cardiac function in healthy volunteers. This study was conducted to evaluate the acute hemodynamic effects of IGF-I in patients with chronic heart failure Eight patients with chronic heart failure were randomized to receive recombinant human IGF-I (60 micrograms/kg) or placebo, i.v., over 4 h in a cross-over, double… CONTINUE READING

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