Acute cardiovascular effects of dimethylsulfoxide.

  title={Acute cardiovascular effects of dimethylsulfoxide.},
  author={Stuart R. Hameroff and Charles W. Otto and J S Kanel and Philip R. Weinstein and Casey D. Blitt},
  journal={Critical care medicine},
  volume={9 12},
Dimethylsulfoxide (DMSO) has been advocated as a central nervous system (CNS) protectant against ischemia and trauma. The present study was performed to evaluate acute cardiovascular effects of DMSO which might complicate the clinical treatment of CNS compromised patients. Intravenously administered DMSO in doses which reportedly provide CNS protection, 2 g/kg, were infused in 6 dogs; hemodynamic variables were measured and compared to infusion of equal volumes of 0.9% sodium chloride… CONTINUE READING