Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1.

  title={Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1.},
  author={Daniel J. Conklin},
  journal={Annals of the New York Academy of Sciences},
  volume={1374 1},
Inhalation of high-level volatile aldehydes, as present in smoke from wildfires and in tobacco smoke, is associated with both acute and chronic cardiopulmonary morbidity and mortality, but the underlying mechanisms are unclear. The transient receptor potential ankyrin 1 (TRPA1) protein forms a cation channel (irritant receptor) that mediates tobacco smoke-induced airway and lung injury, yet the role of TRPA1 in the cardiovascular toxicity of aldehyde exposure is unclear. Physiologically, airway… CONTINUE READING
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