Acute canine distemper encephalitis is associated with rapid neuronal loss and local immune activation.

@article{Rudd2010AcuteCD,
  title={Acute canine distemper encephalitis is associated with rapid neuronal loss and local immune activation.},
  author={Penny A. Rudd and Louis-Etienne Bastien-Hamel and Veronika von Messling},
  journal={The Journal of general virology},
  year={2010},
  volume={91 Pt 4},
  pages={980-9}
}
For most virus infections of the central nervous system (CNS), immune-mediated damage, the route of inoculation and death of infected cells all contribute to the pathology observed. To investigate the role of these factors in early canine distemper neuropathogenesis, we infected ferrets either intranasally or intraperitoneally with the neurovirulent canine distemper virus strain Snyder Hill. Regardless of the route of inoculation, the virus primarily targeted the olfactory bulb, brainstem… CONTINUE READING

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