Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses.

  title={Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses.},
  author={Uwe Koedel and Ulrike Michaela Merbt and Caroline Bergstro Schmidt and Barbara Angele and Bernadette Popp and Hermann Wagner and H. -W. Pfister and Carsten J Kirschning},
  journal={The American journal of pathology},
  volume={171 1},
Endogenous molecules released from disrupted cells and extracellular matrix degradation products activate Toll-like receptors (TLRs) and, thus, might contribute to immune activation after tissue injury. Here, we show that aseptic, cold-induced cortical injury triggered an acute immune response that involves increased production of multiple cytokines/chemokines accompanied by neutrophil recruitment to the lesion site. We observed selective reductions in injury-induced cytokine/chemokine… CONTINUE READING


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