Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein.

@article{DiazArrastia2014AcuteBO,
  title={Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein.},
  author={Ramon R Diaz-Arrastia and Kevin K W Wang and Linda Papa and Marco Sorani and John K. Yue and Ava M. Puccio and Paul J. McMahon and Tomoo Inoue and Esther L. Yuh and Hester F. Lingsma and Andrew I. R. Maas and Alex B. Valadka and David O. Okonkwo and Geoffrey T. Manley},
  journal={Journal of neurotrauma},
  year={2014},
  volume={31 1},
  pages={
          19-25
        }
}
Biomarkers are important for accurate diagnosis of complex disorders such as traumatic brain injury (TBI). For a complex and multifaceted condition such as TBI, it is likely that a single biomarker will not reflect the full spectrum of the response of brain tissue to injury. Ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) are among of the most widely studied biomarkers for TBI. Because UCH-L1 and GFAP measure distinct molecular events, we hypothesized that… CONTINUE READING
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