Acute biological effects of intratracheally instilled titanium dioxide whiskers compared with nonfibrous titanium dioxide and amosite in rats.

@article{Ishihara1999AcuteBE,
  title={Acute biological effects of intratracheally instilled titanium dioxide whiskers compared with nonfibrous titanium dioxide and amosite in rats.},
  author={Yoko Ishihara and Hiroko Kyono and Norihiko Kohyama and Noriko Otaki and Fumio Serita and Tadao Toya and Jun Kagawa},
  journal={Inhalation toxicology},
  year={1999},
  volume={11 2},
  pages={
          131-49
        }
}
The dimensions of man-made mineral fiber whiskers are similar to those of some kinds of asbestos. Thus these mineral fibers raise the concern for potential health hazard for workers exposed in the occupational environments. This study was designed to define acute biological effects of intratracheally administered titanium dioxide whiskers (TO1) compared with nonfibrous titanium dioxide (TOP) and UICC amosite (Ams), and their relations to acute lung inflammation in rats. The observed geometric… CONTINUE READING
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