Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells.

@article{Ellison2007AcuteBO,
  title={Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells.},
  author={Georgina M. Ellison and Daniele Torella and Ioannis Karakikes and Saranya Purushothaman and Antonio Curcio and Cosimo Gasparri and Ciro Indolfi and Nigel Tim Cable and David F. Goldspink and Bernardo Nadal-Ginard},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 15},
  pages={11397-409}
}
A hyperadrenergic state is a seminal aspect of chronic heart failure. Also, "Takotsubo stress cardiomyopathy," is associated with increased plasma catecholamine levels. The mechanisms of myocyte damage secondary to excess catecholamine exposure as well as the consequence of this neurohumoral burst on cardiac stem cells (CSCs) are unknown. Cardiomyocytes and CSCs were exposed to high doses of isoproterenol (ISO), in vivo and in vitro. Male Wistar rats received a single injection of ISO (5 mg kg… CONTINUE READING