Acute behavioural responses to nicotine and nicotine withdrawal syndrome are modified in GABA(B1) knockout mice.

@article{Varani2012AcuteBR,
  title={Acute behavioural responses to nicotine and nicotine withdrawal syndrome are modified in GABA(B1) knockout mice.},
  author={Andr{\'e}s P. Varani and Lirane Machado Moutinho and Bernhard Bettler and Graciela N Balerio},
  journal={Neuropharmacology},
  year={2012},
  volume={63 5},
  pages={863-72}
}
Nicotine is the main active component of tobacco, and has both acute and chronic pharmacological effects that can contribute to its abuse potential in humans. The aim of the present study was to evaluate a possible role of GABA(B) receptors in acute and chronic responses to nicotine administration, by comparing GABA(B1) knockout mice and their wild-type littermates. In wild-type mice, acute nicotine administration (0.5, 1, 3 and 6 mg/kg, sc) dose-dependently decreased locomotor activity, and… CONTINUE READING

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