Acute behavioral toxicity of the organophosphate sarin in rats.

  title={Acute behavioral toxicity of the organophosphate sarin in rats.},
  author={Michael R. Landauer and James A. Romano},
  journal={Neurobehavioral toxicology and teratology},
  volume={6 3},
Three experiments were performed to determine the behavioral effects of acutely administered isopropyl methylphosphonofluoridate, sarin (61-115 micrograms/kg, SC) to male rats. Dosages of 71 micrograms/kg or greater produced conditioned flavor aversions while spontaneous locomotor activity was increased at 61 micrograms/kg and significantly decreased at dosages of 84 to 115 micrograms/kg, when compared to vehicle control levels. Significant decrements in rotorod performance were observed at 98… CONTINUE READING

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