• DOI:10.1007/BF00216067
Corpus ID: 29934652

Acute barbiturate administration increases benzodiazepine receptor binding in vivo

@article{Miller2004AcuteBA,
  title={Acute barbiturate administration increases benzodiazepine receptor binding in vivo},
  author={L. Miller and S. Deutsch and D. Greenblatt and S. Paul and R. Shader},
  journal={Psychopharmacology},
  year={2004},
  volume={96},
  pages={385-390}
}

L. Miller, S. Deutsch, +2 authors R. Shader

Published 2004

Chemistry, Medicine

Psychopharmacology

Barbiturates have been reported to augment benzodiazepine receptor affinity in vitro, but their effects in vivo are uncertain. We determined benzodiazepine receptor binding in vivo by specific uptake of [3H]Ro15-1788 after barbiturate administration. Pentobarbital (30 mg/kg) increased receptor binding in cerebral cortex and cerebellum at 30 min after injection, with a peak effect occurring at 1 h after dosage, and a return to control levels at 2 h. Specific binding was increased at 1 h after… CONTINUE READING

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