Acute barbiturate administration increases benzodiazepine receptor binding in vivo

@article{Miller2004AcuteBA,
  title={Acute barbiturate administration increases benzodiazepine receptor binding in vivo},
  author={L. Miller and S. Deutsch and D. Greenblatt and S. Paul and R. Shader},
  journal={Psychopharmacology},
  year={2004},
  volume={96},
  pages={385-390}
}
  • L. Miller, S. Deutsch, +2 authors R. Shader
  • Published 2004
  • Chemistry, Medicine
  • Psychopharmacology
  • Barbiturates have been reported to augment benzodiazepine receptor affinity in vitro, but their effects in vivo are uncertain. We determined benzodiazepine receptor binding in vivo by specific uptake of [3H]Ro15-1788 after barbiturate administration. Pentobarbital (30 mg/kg) increased receptor binding in cerebral cortex and cerebellum at 30 min after injection, with a peak effect occurring at 1 h after dosage, and a return to control levels at 2 h. Specific binding was increased at 1 h after… CONTINUE READING
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