Acute barbiturate administration increases benzodiazepine receptor binding in vivo

  title={Acute barbiturate administration increases benzodiazepine receptor binding in vivo},
  author={L. Miller and S. Deutsch and D. Greenblatt and S. Paul and R. Shader},
  • L. Miller, S. Deutsch, +2 authors R. Shader
  • Published 2004
  • Chemistry, Medicine
  • Psychopharmacology
  • Barbiturates have been reported to augment benzodiazepine receptor affinity in vitro, but their effects in vivo are uncertain. We determined benzodiazepine receptor binding in vivo by specific uptake of [3H]Ro15-1788 after barbiturate administration. Pentobarbital (30 mg/kg) increased receptor binding in cerebral cortex and cerebellum at 30 min after injection, with a peak effect occurring at 1 h after dosage, and a return to control levels at 2 h. Specific binding was increased at 1 h after… CONTINUE READING
    10 Citations
    Toxin-related seizures.
    • 14
    • PDF
    Anxiety disorder: An overview
    • 3
    A questionable diagnosis in a woman with drowsiness
    Anxiolytika und Hypnotika
    • 3


    Benzodiazepine receptor occupancy in vivo: correlation with brain concentrations and pharmacodynamic actions.
    • 93
    Barbiturate receptor sites are coupled to benzodiazepine receptors.
    • 219
    • PDF
    Interactions of barbiturates of various pharmacological categories with benzodiazepine receptors.
    • 71
    [3H]Ro 15-1788 binding to benzodiazepine receptors in mouse brain in vivo: marked enhancement by GABA agonists and other CNS drugs.
    • 24
    Changes in mouse brain diazepam receptor binding after phenobarbital administration.
    • 19