Acute bacterial rhinosinusitis and otitis media: Changes in pathogenicity following widespread use of pneumococcal conjugate vaccine

@article{Benninger2008AcuteBR,
  title={Acute bacterial rhinosinusitis and otitis media: Changes in pathogenicity following widespread use of pneumococcal conjugate vaccine},
  author={Michael S Benninger},
  journal={Otolaryngology–Head and Neck Surgery},
  year={2008},
  volume={138},
  pages={274 - 278}
}
  • M. Benninger
  • Published 2008
  • Medicine
  • Otolaryngology–Head and Neck Surgery
OBJECTIVE: Acute bacterial rhinosinusitis and acute otitis media are two of the most common respiratory tract infections. The common pathogenic bacteria associated with these infections are Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus. With the recent widespread use of pneumococcal conjugate vaccine, there is evidence that there is a shift of both the pneumococcal serotypes and the distribution of pathogenic bacteria. The purpose of this… Expand
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References

SHOWING 1-10 OF 37 REFERENCES
Pathogen Shifts and Changing Cure Rates for Otitis Media and Tonsillopharyngitis
TLDR
Pneumococcal conjugate vaccine use has caused a decrease in the incidence of recurrent and refractory acute otitis media in the United States and a shift in the predominant pathogens, which has implications for optimal antibiotic therapy. Expand
Efficacy of a pneumococcal conjugate vaccine against acute otitis media.
TLDR
The heptavalent pneumococcal polysaccharide-CRM197 conjugate vaccine is safe and efficacious in the prevention of acute otitis media caused by the serotypes included in the vaccine. Expand
Staphylococcus aureus is a major pathogen in acute bacterial rhinosinusitis: a meta-analysis.
  • S. Payne, M. Benninger
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2007
TLDR
The prevalence of S. aureus among sinus cultures warrants its reconsideration as a major pathogen in acute bacterial rhinosinusitis, and increasing trends of drug-resistant strains may complicate antibiotic recommendations. Expand
Disease Severity in Acute Bacterial Rhinosinusitis is Greater in Patients Infected with Streptococcus Pneumoniae Than in Those Infected with Haemophilus Influenzae
  • M. Benninger, I. Brook, D. Farrell
  • Medicine
  • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2006
TLDR
In acute bacterial rhinosinusitis, infection with S. pneumoniae is associated with more severe clinical symptoms and radiographic total opacification findings than infection with H. influenzae. Expand
Community-Wide Vaccination with the Heptavalent Pneumococcal Conjugate Significantly Alters the Microbiology of Acute Otitis Media
TLDR
The overall proportion of S. pneumoniae isolates and vaccine serotypes in AOM were significantly reduced by community-wide use of PCV7 vaccine in the practice of this 7-clinician, pediatric practice in rural central Kentucky. Expand
Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children
TLDR
A natural competition between colonisation with vaccine-type pneumococci and S aureus, which might explain the increase in S a Aureus-related otitis media after vaccination, is suggested. Expand
Ability of Pneumococcal Serotypes and Clones To Cause Acute Otitis Media: Implications for the Prevention of Otitis Media by Conjugate Vaccines
TLDR
It is concluded that serotype replacement may reduce the long-term efficacy of these vaccines against AOM. Expand
Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children
TLDR
This heptavalent pneumococcal conjugate appears to be highly effective in preventing invasive disease in young children and to have a significant impact on otitis media. Expand
Frequency of recovery of pathogens from the nasopharynx of children with acute maxillary sinusitis before and after the introduction of vaccination with the 7-valent pneumococcal vaccine.
TLDR
It is illustrated that a significant shift occurred in the causative pathogens of acute maxillary sinusitis in children in the 5 years after the introduction of vaccination of children with the PCV7 as compared to the previous 5 years. Expand
Impact of Pneumococcal Conjugate Vaccine and of Reduction of Antibiotic Use on Nasopharyngeal Carriage of Nonsusceptible Pneumococci in Children With Acute Otitis Media
TLDR
Implementation of PCV7, combined with a reduction in antibiotic use, in a country with a high prevalence of antibiotic-resistant pneumococci appears to have a strong impact on the carriage of penicillin nonsusceptible pneumitis in children with AOM. Expand
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