Acute bacterial otitis externa: efficacy and safety of topical treatment with an antibiotic ear drop formulation in comparison to glycerol treatment

  title={Acute bacterial otitis externa: efficacy and safety of topical treatment with an antibiotic ear drop formulation in comparison to glycerol treatment},
  author={Ralph M{\"o}sges and Christian Baues and T Schr{\"o}der and Kurtulus Sahin},
  journal={Current Medical Research and Opinion},
  pages={871 - 878}
Abstract Objectives: To demonstrate the efficacy and safety of an antibiotic ear drop formulation combining polymyxin B sulfate, neomycin sulfate and gramicidin (PS) in patients with acute bacterial otitis externa (AOE). The combination was compared to glycerol ear drops, a non-pharmacologic treatment of AOE. Methods: An active controlled, double-blind, randomized, parallel group, multicenter clinical trial study design was performed in ear, nose and throat (ENT) practices with a planned… 

Prevalence and clinical characteristics of otitis externa among patients attending Otorhinolaryngology Department at Muhimbili National Hospital, Tanzania

Otitis externa was found to be prevalent and with male predominance at Muhimbili National Hospital, Tanzania’s largest tertiary hospital and self-ear cleansing was the commonest risk factor.

Gramicidin Peptide to Combat Antibiotic Resistance: A Review

This review focuses on providing an overview of antimicrobial peptide gramicidin and its types, structures, its interaction with the membranes/lipid bilayers, functions, stability, and uses and the challenges to enhance the gramicIDin peptide for further use as an efficient effective therapeutic peptide in the pharmaceutical industries.

Isolation and Characterization of a New Endophytic Actinobacterium Streptomyces californicus Strain ADR1 as a Promising Source of Anti-Bacterial, Anti-Biofilm and Antioxidant Metabolites

A new strain of endophytic actinobacterium was isolated from the plant Datura metel, which produced secondary metabolites with potent anti-infective activities, and an insight into different classes of compounds produced by the strain ADR1 was obtained by chemical profiling and GC-MS analysis, wherein several therapeutic classes were discovered.

Optical Clearing Agents for Optical Imaging Through Cartilage Tympanoplasties: A Preclinical Feasibility Study

  • Junzhe WangG. Chawdhary R. Adamson
  • Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2022
Optical clearing agents offer a potential pathway towards optical coherence tomography imaging of the middle ear in post-surgical ears with cartilage grafts.

In silico identification of novel peptides with antibacterial activity against multidrug resistant Staphylococcus aureus

HG2 and HG4, the AMPs identified in this study show promise as effective therapies for the treatment of methicillin resistant Staphylococcus aureus infections both in vitro and in vivo whilst having little cytotoxicity against human primary cells, a step forward in the fight against MDR infections.


  • Medicine, Biology
  • 2017
This study aims to compare the efficacy of polymyxin B, neomycin, hydrocor sone in the treatment of acute AOE with the choice for first-line therapy when the tympanic membrane is intact.

Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs

Focus is on the developments reported in the last decade of peptidomimetics with a modular structure of residues connected via amide linkages with respect to their design, synthesis, antimicrobial activity, cytotoxic side effects as well as their potential applications as anti-infective agents.

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Modification of GS enables production of novel derivatives potentially useful for systemic treatment of human infections, and it is shown that derivative VK7 has a lower MIC than GS against strains of multi-drug resistant (MDR) Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa.



A group III steroid solution without antibiotic components: an effective cure for external otitis

BD proved a significantly more effective cure than HCPB during the acute phase of external otitis and afforded a lower relapse frequency during a six-month follow-up period, and price favours a solution without any antibiotic component.

Clinical efficacy of three common treatments in acute otitis externa in primary care: randomised controlled trial

Ear drops containing corticosteroids are more effective than acetic acid ear drops in the treatment of acute otitis externa in primary care and Steroid and acetic Acid or steroid and antibiotic ear drops are equally effective.

Comparison of efficacy and safety of ciprofloxacin otic solution 0.2% versus polymyxin B-neomycin-hydrocortisone in the treatment of acute diffuse otitis externa*.

E efficacy, good tolerability, and ease of administration make ciprofloxacin otic solution 0.2% without a topical steroid an attractive option for the treatment of acute otitis externa.

Otitis externa: clinical comparison of local ciprofloxacin versus local oxytetracycline, polymyxin B, hydrocortisone combination treatment.

Ciprofloxacin appears to be a useful and effective agent in the local therapy of otitis externa and microbiological evaluation showed rapid eradication of all bacterial pathogens in the cipro Floxinacin group with 1 persistence of Candida albicans but eradication in the same ear with marked clinical improvement.

Diffuse Otitis Externa: Clinical and Microbiologic Findings in the Course of a Multicenter Study on a New Otic Solution

  • Nicholas CassisiArnold CohnTerence DavidsonB. Witten
  • Medicine
    The Annals of otology, rhinology & laryngology. Supplement
  • 1977
A high degree of clinical and bacteriologic efficacy was demonstrated by the medications irrespective of the formulation, infecting organism, patient's age, length of disease history, severity, or geographic location.

Ofloxacin otic solution for treatment of otitis externa in children and adults.

Ofloxacin given twice daily is as safe and effective as Cortisporin given 4 times daily for otitis externa and the bacteriological findings and treatment responses do not differ between adults and children.

A clinical comparison of hydrocortisone butyrate with oxytetracycline/hydrocortisone acetate -polymyxin B in the local treatment of acute external otitis

Although the butyrate solution did not contain any antibiotic supplement, it seemed to be more effective than TPB in treating the staphylococcal infections, and such other factors as the hydrogen ion concentration, the steroid potency or the vehicle per se are of importance for the successful treatment of acute external otitis.

Microbiology of Acute Otitis Media with Tympanostomy Tubes

  • P. RolandD. ParryD. Stroman
  • Medicine, Biology
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2005

Use of Ototopical Antibiotics in Treating 3 Common Ear Diseases

  • M. HannleyJ. DennenyS. Holzer
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2000
The Panel concluded that in the absence of systemic infection or serious underlying disease, topical antibiotics alone constitute first-line treatment for most patients with these conditions, finding no evidence that systemic antibiotics alone or in combination with topical preparations improve treatment outcomes compared with topical antibiotic alone.