Acute astrocyte activation in brain detected by MRI: new insights into T(1) hypointensity.

@article{Sibson2007AcuteAA,
  title={Acute astrocyte activation in brain detected by MRI: new insights into T(1) hypointensity.},
  author={Nicola R. Sibson and John P. Lowe and Andrew M. Blamire and Matthew Jeffrey Martin and Tihomir P. Obrenovitch and Daniel C. Anthony},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2007},
  volume={28 3},
  pages={
          621-32
        }
}
Increases in the T(1) of brain tissue, which give rise to dark or hypointense areas on T(1)-weighted images using magnetic resonance imaging (MRI), are common to a number of neuropathologies including multiple sclerosis (MS) and ischaemia. However, the biologic significance of T(1) increases remains unclear. Using a multiparametric MRI approach and well-defined experimental models, we have experimentally induced increases in tissue T(1) to determine the underlying cellular basis of such changes… CONTINUE READING
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