Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms.

@article{Liu2005AcuteAI,
  title={Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms.},
  author={Rong Liu and J F Pei and Xiao-Chuan Wang and Xinwen Zhou and Q. I. Tian and Bengt Winblad and Jian-Zhi Wang},
  journal={Journal of neurochemistry},
  year={2005},
  volume={94 5},
  pages={1225-34}
}
Abnormal phosphorylation of microtubule-associated protein tau plays a critical role in Alzheimer's disease (AD), together with a distinct decrease of energy metabolism in the affected brain regions. To explore the effect of acute energy crisis on tau phosphorylation and the underlying mechanisms, we incubated rat brain slices in artificial cerebrospinal fluid (aCSF) at 37 degrees C with or without an oxygen supply, or in aCSF with low glucose concentrations. Then, the levels of total… CONTINUE READING