Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline.

@article{Azizi1996AcuteAE,
  title={Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline.},
  author={Michel Azizi and Anne Rousseau and Eric Ezan and Than Tam Guyene and Sandrine Michelet and J. M. Grognet and Maryse Lenfant and Pierre Corvol and Jo{\"e}l M{\'e}nard},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 3},
  pages={839-44}
}
Angiotensin I-converting enzyme (ACE) has two homologous active NH2- and COOH-terminal domains and displays activity toward a broad range of substrates. The tetrapeptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) has been shown to be hydrolyzed in vitro by ACE and to be a preferential substrate for its NH2-terminal active site. This peptide is a regulatory factor of hematopoiesis which reversibly stem cells and normal early progenitors into S-phase. We found that a single oral dose of 50… CONTINUE READING
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