Acute and subchronic toxicity of a nonsulfhydryl angiotensin-converting enzyme inhibitor.

  title={Acute and subchronic toxicity of a nonsulfhydryl angiotensin-converting enzyme inhibitor.},
  author={P. L. La Rocca and R. Squibb and M. Powell and R. Szot and H. E. Black and E. Schwartz},
  journal={Toxicology and applied pharmacology},
  volume={82 1},
  • P. L. La Rocca, R. Squibb, +3 authors E. Schwartz
  • Published 1986
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • Acute and 1-month toxicity studies with SCH 31846, a nonsulfhydryl anti-hypertensive agent which acts by inhibiting angiotensin-converting enzyme, were initiated to evaluate its toxicity. The oral LD50s in mice and rats were approximately 1.8 and 2.5 g/kg, respectively, while the iv LD50 was approximately 450 mg/kg in mice and 150 mg/kg in rats. Signs of acute toxicity in rats and mice included salivation, hypoactivity, ataxia, prostration, and convulsions. In a 1-month dog study at oral doses… CONTINUE READING
    14 Citations
    IX – Urinary Tract
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    10 – Urinary Tract
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    Chapter 7 Antihypertensive Agents
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