• DOI:10.1016/0041-008X(86)90443-6
Corpus ID: 21188592

Acute and subchronic toxicity of a nonsulfhydryl angiotensin-converting enzyme inhibitor.

@article{Rocca1986AcuteAS,
  title={Acute and subchronic toxicity of a nonsulfhydryl angiotensin-converting enzyme inhibitor.},
  author={P. L. La Rocca and R. Squibb and M. Powell and R. Szot and H. E. Black and E. Schwartz},
  journal={Toxicology and applied pharmacology},
  year={1986},
  volume={82 1},
  pages={
          104-11
        }
}

P. L. La Rocca, R. Squibb, +3 authors E. Schwartz

Published 1986

Chemistry, Medicine

Toxicology and applied pharmacology

Acute and 1-month toxicity studies with SCH 31846, a nonsulfhydryl anti-hypertensive agent which acts by inhibiting angiotensin-converting enzyme, were initiated to evaluate its toxicity. The oral LD50s in mice and rats were approximately 1.8 and 2.5 g/kg, respectively, while the iv LD50 was approximately 450 mg/kg in mice and 150 mg/kg in rats. Signs of acute toxicity in rats and mice included salivation, hypoactivity, ataxia, prostration, and convulsions. In a 1-month dog study at oral doses… CONTINUE READING

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