Acute and subchronic effects of Rimcazole (BW 234U), a potential antipsychotic drug, on A9 and A10 dopamine neurons in the rat.
@article{Piontek1986AcuteAS, title={Acute and subchronic effects of Rimcazole (BW 234U), a potential antipsychotic drug, on A9 and A10 dopamine neurons in the rat.}, author={Johann Piontek and R. Y. Wang}, journal={Life sciences}, year={1986}, volume={39 7}, pages={ 651-8 } }
The effects of acute and subchronic Rimcazole administration on A9 and A10 dopamine (DA) neurons were examined using extracellular single cell recording techniques. Intravenous injections of Rimcazole did not prevent or reverse the inhibition of firing rates of DA cells produced by DA agonist apomorphine (APO). Single intraperitoneal injection of Rimcazole decreased the number of spontaneously active DA cells in A10, but not in A9; it had no effect on the firing rate of DA neurons in either A9… CONTINUE READING
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References
SHOWING 1-10 OF 16 REFERENCES
Comparison of the effects of chronic haloperidol treatment on A9 and A10 dopamine neurons in the rat.
- Chemistry, Medicine
- Life sciences
- 1983
- 211
Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons
- Biology, Medicine
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- 1983
- 648
- PDF
Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization
- Biology, Medicine
- Neuroscience
- 1983
- 867
Neuroleptic-induced decrease in plasma homovanillic acid and antipsychotic activity in schizophrenic patients.
- Medicine
- Science
- 1984
- 237
Dopaminergic neurons in the rat ventral tegmental area. I. Identification and characterization
- Chemistry
- Brain Research Reviews
- 1981
- 251
BW234U,(cis‐9‐[3–(3,5‐dimethyl‐1‐piperazinyl)propyl]carbazole dihydrochloride): a novel antipsychotic agent
- Medicine, Chemistry
- The Journal of pharmacy and pharmacology
- 1982
- 53
BW234: A nondopamine receptor‐blocking antipsychotic drug without extrapyramidal side effects?
- Medicine
- 1985
- 13
Catecholamines in the brain as mediators of amphetamine psychosis.
- Psychology, Medicine
- Archives of general psychiatry
- 1972
- 407