Acute and subacute toxicity studies of CMICE-013, a novel iodinated rotenone-based myocardial perfusion tracer, in Sprague Dawley rats and Gottingen minipigs.

  title={Acute and subacute toxicity studies of CMICE-013, a novel iodinated rotenone-based myocardial perfusion tracer, in Sprague Dawley rats and Gottingen minipigs.},
  author={Yin Duan and Xuxu Yan and Lihui Wei and Corinne Bensimon and Pasan Chinthana Fernando and Terrence D. Ruddy},
  journal={Regulatory toxicology and pharmacology : RTP},
  • Yin DuanXuxu Yan T. Ruddy
  • Published 1 October 2016
  • Medicine, Biology
  • Regulatory toxicology and pharmacology : RTP
4 Citations

Nonclinical safety testing of imaging agents, contrast agents and radiopharmaceuticals

  • P. Baldrick
  • Medicine, Biology
    Journal of applied toxicology : JAT
  • 2020
The need for regulatory agency interaction is still vital to avoid development surprises and delays due to an incomplete or badly performed testing package.



Biodistribution and radiodosimetry of a novel myocardial perfusion tracer 123I-CMICE-013 in healthy rats

123I-CMICE-013 demonstrated desirable characteristics in its biokinetic and radiodosimetric profiles, supporting its potential application as a novel myocardial perfusion imaging agent.

Phase I, First-in-Human Study of BMS747158, a Novel 18F-Labeled Tracer for Myocardial Perfusion PET: Dosimetry, Biodistribution, Safety, and Imaging Characteristics After a Single Injection at Rest

Preliminary data suggest that 18F-labeled BMS747158 appears to be well tolerated and has a unique potential for myocardial perfusion PET.

Cardioprotective effect of grape-seed proanthocyanidins on doxorubicin-induced cardiac toxicity in rats

It is suggested that proanthocyanidins might be a potential cardioprotective agent against Dox-induced cardiotoxicity due to its antioxidant properties.

Short-term exposure to low doses of rotenone induces developmental, biochemical, behavioral, and histological changes in fish

L Lethal and sublethal effects of rotenone raise a concern about its effects on nontarget fish species, especially because roten one and its metabolite rotenolone are frequently reported in the microgram range in natural environments for several days after field applications.

Selective microglial activation in the rat rotenone model of Parkinson's disease

Flow-Dependent Uptake of 123I-CMICE-013, a Novel SPECT Perfusion Agent, Compared with Standard Tracers

The CMICE-013 images showed good contrast between the heart and surrounding organs, with heart-to-liver and heart- to-lung uptake ratios similar to those of the standard tracers.

Cardioprotective effect of whole fruit extract of pomegranate on doxorubicin-induced toxicity in rat

Results indicate that WFEP has cardioprotective effect against Dox-induced cardiotoxicity in rats, and shows slight protection against myocardial toxicity induced by Dox.

Cardiac imaging and safety evaluation of BMS747158, a novel PET myocardial perfusion imaging agent, in chronic myocardial compromised rabbits

Cardiac imaging with BMS747158 allows clear detection of chronic MI without producing any cardiovascular alterations in cardiac compromised rabbits.