Acute and sub-chronic toxicity study of diaveridine in Wistar rats

  title={Acute and sub-chronic toxicity study of diaveridine in Wistar rats},
  author={Xu Wang and Shijia Su and Awais Ihsan and Qin Huang and Dongmei Chen and Guyue Cheng and Zhenli Liu and Yulian Wang and Zonghui Yuan},
  journal={Regulatory toxicology and pharmacology : RTP},
  volume={73 1},
Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. However, few studies have been performed to investigate its toxicity. To provide detailed toxicity with a wide spectrum of doses for diaveridine, acute and sub-chronic toxicity studies were conducted. Calculated LD50 was 2330 mg/kg b.w. in females and 3100 mg/kg b.w. in males, and chromodacryorrhea was noted in some females before their death. In the sub-chronic… CONTINUE READING


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