Acute and sub-acute toxicological assessment of the aqueous seed extract of Persea americana mill (Lauraceae) in rats.

@article{Ozolua2009AcuteAS,
  title={Acute and sub-acute toxicological assessment of the aqueous seed extract of Persea americana mill (Lauraceae) in rats.},
  author={Raymond I. Ozolua and Ogochukwu N Anaka and Stephen O Okpo and Sylvester E Idogun},
  journal={African journal of traditional, complementary, and alternative medicines : AJTCAM},
  year={2009},
  volume={6 4},
  pages={573-8}
}
The aqueous seed extract of Persea americana Mill (Lauraceae) is used by herbalists in Nigeria for the management of hypertension. As part of our on-going scientific evaluation of the extract, we designed the present study to assess its acute and sub-acute toxicity profiles in rats. Experiments were conducted to determine the oral median lethal dose (LD(50)) and other gross toxicological manifestations on acute basis. In the sub-acute experiments, the animals were administered 2.5 g/kg (p.o… CONTINUE READING
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