Acute and short-term insulin-induced molecular adaptations of GLUT2 gene expression in the renal cortex of diabetic rats

@article{Freitas2005AcuteAS,
  title={Acute and short-term insulin-induced molecular adaptations of GLUT2 gene expression in the renal cortex of diabetic rats},
  author={H. Freitas and B. Schaan and P. M. Seraphim and M. Nunes and U. Machado},
  journal={Molecular and Cellular Endocrinology},
  year={2005},
  volume={237},
  pages={49-57}
}
  • H. Freitas, B. Schaan, +2 authors U. Machado
  • Published 2005
  • Medicine, Biology
  • Molecular and Cellular Endocrinology
  • Increased GLUT2 gene expression in the renal proximal tubule of diabetic rats is an adaptive condition, which may be important in the diabetic nephropathy development. We investigated the effects of insulin treatment upon the renal GLUT2 overexpression of diabetic rats. Acute treatment, surprisingly, induced a rapid further increase in GLUT2 mRNA content. Twelve hours after insulin injection, GLUT2 mRNA was twice the value of saline-injected rats (P<0.001), when GLUT2 protein remained unchanged… CONTINUE READING
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