Acute and short-term effects of the nonpeptide endothelin-1 receptor antagonist bosentan in humans


In recent years, evidence from various animal experiments has accumulated that emphasizes the role of endothelin-1 in the pathophysiology of several cardiovascular diseases, including congestive heart failure. The recent advent of potent antagonists of this system now allows the assessment of the involvement of endothelin-1 in the maintenance of vascular… (More)
DOI: 10.1007/BF00053029


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