Acute and repeated administration of sulpiride alters Met-and Leu-enkephalin content of rat brain.

@article{Ceballos1986AcuteAR,
  title={Acute and repeated administration of sulpiride alters Met-and Leu-enkephalin content of rat brain.},
  author={Maria L de Ceballos and P Feroz Jenner and C. David Marsden},
  journal={Neuroscience letters},
  year={1986},
  volume={68 3},
  pages={322-6}
}
Following acute administration of sulpiride (100 mg/kg, i.p.), Met-enkephalin levels were increased in striatum but decreased in substantia nigra and nucleus accumbens. No effect was observed in hypothalamus or frontal cortex. In contrast, Leu-enkephalin content was decreased in the nucleus accumbens but not elsewhere. Administration of sulpiride (10 or 100 mg/kg, i.p.) for 21 days, followed by 2 days drug withdrawal, caused a dose-dependent increase in Met-enkephalin in nucleus accumbens but… CONTINUE READING