Acute and multiple-dose studies to determine the safety, tolerability, and pharmacokinetic profile of advantame in healthy volunteers.

@article{Warrington2011AcuteAM,
  title={Acute and multiple-dose studies to determine the safety, tolerability, and pharmacokinetic profile of advantame in healthy volunteers.},
  author={Steven J Warrington and C Lee and Akira Otabe and Tatsuya Narita and O Polnjak and Valdis Pīrāgs and Dainis Krieviņ{\vs}},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2011},
  volume={49 Suppl 1},
  pages={S77-83}
}
Advantame, a new, high-intensity sweetener that is thought not to be absorbed from the human gastrointestinal tract in appreciable quantities, was evaluated for safety and tolerability in a total of 48 healthy adult volunteers in 2 studies. In the first study 24 subjects were randomized to receive escalating single doses of 0.1, 0.25, or 0.5mg/kg of body weight, and pharmacokinetic and safety parameters were assessed subsequently for 8 days. In the second study, 24 subjects were randomized to… CONTINUE READING

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