Acute and long-term response to an oral converting-enzyme inhibitor, captopril, in congestive heart failure.

@article{Levine1980AcuteAL,
  title={Acute and long-term response to an oral converting-enzyme inhibitor, captopril, in congestive heart failure.},
  author={T. Barry Levine and Joseph A. Franciosa and Jay N. Cohn},
  journal={Circulation},
  year={1980},
  volume={62 1},
  pages={35-41}
}
Captopril (SQ 14,225), an oral angiotensin converting-enzyme inhibitor, was administered to 11 patients with severe congestive heart failure (CHF). Peak effect was observed at 1.5 hours after administration. At peak effect right atrial pressure fell from 3.4 to 0.0 mm Hg, pulmonary capillary wedge pressure (PCW) fell from 22.7 to 12.3 mm Hg, mean arterial pressure (MAP) fell from 79.5 to 62.1 mm Hg, systemic vascular resistance (SVR) fell from 1989 to 1370 dyn-sec-cm-5, pulmonary vascular… CONTINUE READING

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