Acute and delayed effect of (−) deprenyl and (−) 1‐phenyl‐2‐propylaminopentane (PPAP) on the serotonin content of peritoneal cells (white blood cells and mast cells)

@article{Csaba2006AcuteAD,
  title={Acute and delayed effect of (−) deprenyl and (−) 1‐phenyl‐2‐propylaminopentane (PPAP) on the serotonin content of peritoneal cells (white blood cells and mast cells)},
  author={Gy{\"o}rgy Csaba and P{\'e}ter Kov{\'a}cs and {\'E}va Pallinger},
  journal={Cell Biochemistry and Function},
  year={2006},
  volume={24}
}
Acute and delayed (hormonal imprinting) effect of (−) deprenyl and its derivative without MAO‐B inhibitory activity (−) PPAP, were studied on cells of the peritoneal fluid (lymphocytes, monocytes, granulocytes and mast cells) by flow cytometric and confocal microscopic analysis. Thirty minutes after treatment of 6‐week‐old female animals, deprenyl was ineffective while PPAP significantly increased the serotonin level of these cells. Three weeks after treatment at weaning, deprenyl drastically… 
1 Citations
Immunoendocrinology: faulty hormonal imprinting in the immune system.
  • G. Csaba
  • Biology
    Acta microbiologica et immunologica Hungarica
  • 2014
TLDR
F faulty imprinting is inherited to the progenies in general and especially in the case of immune system, and the present and future consequences of the flood of faulty imprintings are unpredictable however, it is discussed.

References

SHOWING 1-10 OF 24 REFERENCES
Antiaging compounds: (-)deprenyl (selegeline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective highly potent enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain.
TLDR
This review summarizes the physiologic and pharmacologic arguments in favor of a peculiar lifelong prophylactic medication with reasonable chances to keep in check brain aging and decrease the precipitation of age-related neurological diseases.
(-)Deprenyl (selegiline), a catecholaminergic activity enhancer (CAE) substance acting in the brain.
  • J. Knoll
  • Biology, Psychology
    Pharmacology & toxicology
  • 1998
TLDR
It may be supposed that a prophylactic low dose administration of a safe catecholaminergic activity enhancer substance during the postdevelopmental phase of life will slow the age-related decline of behavioral performances, delay natural death and decrease susceptibility to Parkinson's disease and Alzheimer's disease.
Inhibition of tumor growth by L-deprenyl involves neural-immune interactions in rats with spontaneously developing mammary tumors.
TLDR
The results suggest that the anti-tumor effects of deprenyl on spontaneous rat mammary tumors may be achieved via neural-immune signaling in the spleen and medial basal hypothalamus.
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