Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents

@article{Griebel1994AcuteAC,
  title={Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents},
  author={Guy Griebel and J. V. Moreau and François Jenck and Ren{\'e} Misslin and James R. Martin},
  journal={Psychopharmacology},
  year={1994},
  volume={113},
  pages={463-470}
}
This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In addition, the responses of mice to novelty in a free exploration paradigm were assessed after acute administration of both drugs. A single injection of cianopramine or citalopram… CONTINUE READING

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