Acute and chronic toxicity studies of Erythrina senegalensis DC stem bark extract in mice

@article{Udem2009AcuteAC,
  title={Acute and chronic toxicity studies of Erythrina senegalensis DC stem bark extract in mice},
  author={Samuel Chukwuneke Udem and Onyechi Obidoa and Isaac Uzoma Asuzu},
  journal={Comparative Clinical Pathology},
  year={2009},
  volume={19},
  pages={275-282}
}
The toxicity of chloroform stem bark extract of Erythrina senegalensis DC, a medicinal plant with anti-inflammatory activity, was studied in vivo and in vitro. The LD50 i.p. of the extract was 526 mg/kg after an acute toxicity test (24 h). A brine shrimp lethality test with the extract gave LC50 of 60.86 ppm. The chronic studies revealed alterations in the levels of biochemical markers of hepatic and cardiac damage. The alterations were, however, not significant except in the group fed the… CONTINUE READING
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